First-in-class therapy targets 鈥渦ndruggable鈥 protein in hard-to-treat blood cancers
The MYC protein is involved in about 70% of cancers, but scientists have been unable to develop drugs that effectively block it
Researchers discovered a dependent relationship in which MYC and another protein support each other in a reinforcing cycle
A new therapy interrupts the cycle, causing levels of both proteins to drop significantly
Preclinical findings demonstrated strong anti-cancer activity in multiple...
Scientists uncover drivers of recurrent arthritis after immunotherapy, suggesting potential biomarkers
Some patients receiving immunotherapy can develop recurrent inflammatory arthritis that often worsens in subsequent flare-ups
Researchers...
Immune cell dysfunction, not absence, defines skin cancer in immunosuppressed patients
Patients with weakened immune systems develop non-melanoma skin cancers that are more frequent, more aggressive, and more often lethal聽...
Reshaping the gut microbiome can boost chemotherapy delivery to tumors
Nanoparticle-based chemotherapy is widely used but liver clearance often limits its effectiveness聽
The gut microbiome regulates how aggressively the liver clears these drugs from the bloodstream
A common antibiotic reshaped gut bacteria in preclinical models, significantly reducing liver clearance and doubling how long chemotherapy remained in circulation to reach tumors
The findings demonstrate that...
Targeting a signaling pathway activated by acidic tumor environment restores treatment response to PARP inhibitors in ovarian cancer
PARP inhibitors are among the most widely used therapies for ovarian cancer, but their long-term effectiveness is limited by acquired resistance...
Epigenetic therapy shows promise against treatment-resistant AML
Next-generation epigenetic therapy showed stronger anti-leukemia activity than current standard treatments in preclinical models of acute...
Fasting primes gut microbiome to improve intestinal recovery after radiation treatment
Researchers identified a gut bacterium that helps prime intestinal stem cells for faster recovery
In preclinical models, short-term...
Biomarker-guided drug combinations may improve outcomes in treatment-resistant melanoma
In a preclinical study, adding a BCL2 inhibitor to standard melanoma therapy shrank tumors that had stopped responding to therapy
The study...
Study identifies a new cause of age-related inflammation, suggesting promising treatment pathway
As cells age, they increasingly export nucleic acid structures called R-loops from the nucleus, triggering an immune response that causes...